Andrographolide blocks 50-kHz ultrasonic vocalizations, hyperlocomotion and oxidative stress in an animal model of mania

نویسندگان

چکیده

In rats, lisdexamfetamine (LDX) induces manic-like behaviors such as hyperlocomotion and increases in appetitive 50-kHz ultrasonic vocalizations (USV), which are prevented by antimanic drugs, lithium. Inhibition of glycogen synthase kinase 3 beta (GSK3?) antioxidant activity have been associated with effects. Thus, the aim present study was to evaluate possible antimanic-like effects andrographolide (ANDRO), a GSK3? inhibitor, on LDX-induced USV increases. addition, effect ANDRO studied oxidative stress. Lithium used positive control. Adult Wistar rats were treated vehicle, lithium (100 mg/kg i.p., daily) or (2 times week) for 21 days. On test day, either 10 LDX saline administered i.p. locomotor recorded. administration increased number calls, well activity. Repeated treatment these lipid peroxidation (LPO) levels rat striatum both this effect. LPO positively correlated emission hyperlocomotion. conclusion, results indicate that has effects, may be mediated its properties. • Andrographolide (LDX)-induced vocalizations. striatal

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ژورنال

عنوان ژورنال: Journal of Psychiatric Research

سال: 2021

ISSN: ['0022-3956', '1879-1379']

DOI: https://doi.org/10.1016/j.jpsychires.2021.05.042