Androgens and mammalian male reproductive tract development
نویسندگان
چکیده
منابع مشابه
Mammalian reproductive tract mucins.
Mucin glycoproteins are major constituents of the glycocalyx that covers mucosal epithelium. Two broad classes of mucins exist: membrane-associated and secretory. Of the secreted mucins, those with cysteine-rich regions are thought to polymerize through disulphide bonds. Among these gel-forming mucins are MUC2, MUC5AC, MUC5B and possibly MUC6. MUC7 lacks cysteine-rich domains and is thought to ...
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Androgens are steroid hormones that play key roles in the development and maintenance of male phenotype and reproductive function. These hormones also affect the function of several non-reproductive organs, such as bone and skeletal muscle. Endogenous androgens exert most of their effects by genomic mechanisms, which involve hormone binding to the androgen receptor (AR), a ligand-activated tran...
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The development of the male reproductive tract is dependent upon androgens and mesenchymal-epithelial interactions. Androgens masculinise the reproductive tract during the latter third of gestation, and are required for the formation of the male sex accessory organs including the prostate and seminal vesicle (Cunha et al., 1987). Studies using tissue recombination have shown that androgen recep...
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Infertility is an uncommon manifestation of genitourinary tract tuberculosis. Anatomic obstruction by granulomas or distortion of the normal anatomy by fibrosis surrounding the reproductive tract structures is the commonest cause of infertility. The diagnosis is usually based on a suggestive history along with evidence of granulomatous infection on a tissue sample. The management depends on the...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
سال: 2015
ISSN: 1874-9399
DOI: 10.1016/j.bbagrm.2014.05.020