Androgen receptor gene GGN and CAG polymorphisms among severely oligozoospermic and azoospermic Swedish men
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چکیده
منابع مشابه
Androgen receptor gene GGN and CAG polymorphisms among severely oligozoospermic and azoospermic Swedish men.
BACKGROUND We investigated the androgen receptor gene GGN polymorphism and its relation to male infertility and receptor function. METHODS Ninety-nine infertile patients with sperm counts < or = 5 x 10(6)/ml were screened for karyotypic abnormalities and Y-chromosome microdeletions. The GGN and CAG repeats were sequenced in those without genetic abnormalities and in 223 controls. RESULTS Fi...
متن کاملAndrogen receptor gene CAG and GGN repeat polymorphisms in Chilean men with primary severe spermatogenic failure.
There is ample documentation supporting the fact that androgens are required for normal spermatogenesis. A minority of infertile men have abnormal testosterone blood levels or mild androgen receptor mutations. We investigated the androgen receptor CAG and GGN repeat lengths in Chilean men with spermatogenic impairment. We studied 117 secretory azoospermic/oligozoospermic men (93 idiopathic and ...
متن کاملBone Mass and the CAG and GGN Androgen Receptor Polymorphisms in Young Men
BACKGROUND To determine whether androgen receptor (AR) CAG (polyglutamine) and GGN (polyglycine) polymorphisms influence bone mineral density (BMD), osteocalcin and free serum testosterone concentration in young men. METHODOLOGY/PRINCIPAL FINDINGS Whole body, lumbar spine and femoral bone mineral content (BMC) and BMD, Dual X-ray Absorptiometry (DXA), AR repeat polymorphisms (PCR), osteocalci...
متن کاملP-118: Triplet Nucleotide Repeats Expansion (CAG and GGN) of Androgen Receptor Gene in Infertile Patients with Abnormal Spermogram
Background s:648:"The infertility has recently been estimated to affect approximately 9% of couples worldwide. Androgens and a functional androgen receptor (AR) are essential for normal development of the male gender, and for maintenance of spermatogenesis throughout the life. Two polymorphic trinucleotide repeats, CAG and GGN, encoding for the amino acids glutamine and glycine, respectively ar...
متن کاملP-119: Survey of Genetic Alterations in Exon1 of Androgen Receptor Gene in Azoospermic Patients
Background Androgen receptor (AR) mediates androgen actions such as initiation and promotion of spermatogenesis and growth of accessory sex organs. There are two trinucleotide polymorphisms (CAG and GGN repeats) in exon1 of AR gene that are vary in length in population. The CAG and GGN repeats association with infertility is still unknown and this study is planned to assess the distribution of ...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2004
ISSN: 1460-2350
DOI: 10.1093/humrep/deh349