منابع مشابه
Datenbanken - (etwas) anders gesehen
Im Informatikunterricht werden Datenbanken entweder vom Ansatz des Anwendens oder des Modellierens behandelt. Diese beiden Ansätze sind als „Verwenden von Strukturen“ bzw. „Erzeugen von Strukturen“ zueinander komplementär, vernachlässigen aber häufig die Rückkoppelung des durch die Datenbank repräsentierten Modells mit dem modellierten Realweltausschnitt. Dieser Artikel beschreibt erste Erfahru...
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The clinical efficacy of anthracyclines (e.g., doxorubicin and daunorubicin) in cancer therapy is limited by their severe cardiotoxicity, the etiology of which is still not fully understood. The development of anthracycline-induced cardiomyopathy has been found to correlate with myocardial formation and accumulation of anthracycline secondary alcohol metabolites (e.g., doxorubicinol and daunoru...
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In the present study, we conducted a retrospective analysis of 343 in vitro experiments to ascertain whether observed (experimentally determined) values of Ki for reversible cytochrome P450 (P450) inhibition could be reliably predicted by dividing the corresponding IC50 values by two, based on the relationship (for competitive inhibition) in which Ki = IC50/2 when [S] (substrate concentration) ...
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Multidrug resistance–associated protein 1 (MRP1/ABCC1) is an important membrane transporter that contributes to cellular disposition of many endobiotic and xenobiotic agents, and it can also confer multidrug resistance. This study aimed to investigate the role of human noncoding microRNA-1291 (hsa-miR-1291) in regulation of ABCC1 and drug disposition. Bioinformatics analyses indicated that hsa-...
متن کاملDev118950 1733..1744
The segmented vertebral column comprises a repeat series of vertebrae, each consisting of two key components: the vertebral body (or centrum) and the vertebral arches. Despite being a defining feature of the vertebrates, much remains to be understood about vertebral development and evolution. Particular controversy surrounds whether vertebral component structures are homologous across vertebrat...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1993
ISSN: 0022-3050
DOI: 10.1136/jnnp.56.12.1242