Anastrozole sets the STAGE for premenopausal women
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چکیده
منابع مشابه
Anastrozole Use in Early Stage Breast Cancer of Post-Menopausal Women.
The majority of breast cancers express the estrogen receptor and depend on estradiol (E2) for their growth. Hormonal therapy aims at depriving estrogen signaling either by using selective estrogen receptor modulators (SERM)-that interfere with the binding of E2 to its receptor (ER)-or aromatase inhibitors (AI)-that block the aromatase-dependent synthesis of E2. While SERMs are recommended for b...
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With the presentation and publication of the Tamoxifen and Exemestane Trial (TEXT) and the Suppression of Ovarian Function Trial (SOFT) in 2014, along with the Adjuvant Tamoxifen—To Offer More (aTTom) and Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) trials in the last few years, deciding among the standard adjuvant endocrine therapy options for premenopausal women with hormone-sensitive b...
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Endocrine treatment represents the cornerstone of endocrine-sensitive premenopausal early breast cancer. The estrogen blockade plays a leading role in the therapeutic management of hormone receptor-positive breast cancer together with surgery, radiotherapy, and selective antiestrogen treatments. For several years, selective estrogen receptor modulators, such as tamoxifen, have represented the m...
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Enterostatins [Val-Pro-Asp-Pro-Arg (VPDPR), Val-Pro-Gly-Pro-Arg (VPGPR), and Ala-Pro-Gly-Pro-Arg (APGPR)] are pentapeptides derived from the NH2-terminus of procolipase after tryptic cleavage and belong to the family of gut-brain peptides. Although enterostatin-like immunoreactivities exist in blood, brain, and gut, and exogenous enterostatins decrease fat appetite and insulin secretion in rats...
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ژورنال
عنوان ژورنال: Nature Reviews Clinical Oncology
سال: 2012
ISSN: 1759-4774,1759-4782
DOI: 10.1038/nrclinonc.2012.13