Anaplasma phagocytophilum Reduces Neutrophil Apoptosis In Vivo
نویسندگان
چکیده
منابع مشابه
Anaplasma phagocytophilum reduces neutrophil apoptosis in vivo.
Ovine neutrophils spontaneously underwent apoptosis during culture in vitro, as assessed by morphological changes and exposure of annexin V binding sites on their cell surfaces. The addition of conditioned medium from concanavalin A-treated ovine peripheral blood mononuclear cells (PBMC) could partially protect against this progression into apoptosis, but dexamethasone and sodium butyrate could...
متن کاملAnaplasma phagocytophilum delay of neutrophil apoptosis through the p38 mitogen-activated protein kinase signal pathway.
Human granulocytic anaplasmosis is caused by the obligate intracellular bacterium Anaplasma phagocytophilum. The bacterium avoids host innate defenses in part by infecting, surviving in, and propagating in neutrophils, as well as by inhibiting neutrophil apoptosis. However, the mechanisms of A. phagocytophilum survival in neutrophils and the inhibition of spontaneous apoptosis are not well unde...
متن کاملNeutrophil NADPH oxidase is reduced at the Anaplasma phagocytophilum phagosome.
The intracellular organism Anaplasma phagocytophilum causes human granulocytic ehrlichiosis and specifically infects and multiplies in neutrophilic granulocytes. Previous reports have suggested that, for its survival, this bacterium suppresses the neutrophil respiratory burst. To investigate the mechanism of survival, we first assessed the kinetics of A. phagocytophilum entry into neutrophils b...
متن کاملTransformation of Anaplasma phagocytophilum
BACKGROUND Tick-borne pathogens cause emerging zoonoses, and include fastidious organisms such as Anaplasma phagocytophilum. Because of their obligate intracellular nature, methods for mutagenesis and transformation have not been available. RESULTS To facilitate genetic manipulation, we transformed A. phagocytophilum (Ap) to express a green fluorescent protein (GFP) with the Himar1 transposas...
متن کاملAnaplasma phagocytophilum, Sardinia, Italy
1. McQuiston JH, Childs JE. Q fever in humans and animals in the United States. Vector Borne Zoonotic Dis. 2002;2: 179–91. 2. Maurin M, Raoult D. Q fever. Clin Microbiol Rev. 1999;12:518–53. 3. Stoker MGP, Marmion BP. The spread of Q fever from animals to man: the natural history of a rickettsial disease. Bull World Health Organ. 1955;13:781–806. 4. Spicer AJ. Military significance of Q fever: ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2003
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.71.4.1995-2001.2003