Anaplasma phagocytophilum Infection Induces Protracted Neutrophil Degranulation
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چکیده
منابع مشابه
Anaplasma phagocytophilum reduces neutrophil apoptosis in vivo.
Ovine neutrophils spontaneously underwent apoptosis during culture in vitro, as assessed by morphological changes and exposure of annexin V binding sites on their cell surfaces. The addition of conditioned medium from concanavalin A-treated ovine peripheral blood mononuclear cells (PBMC) could partially protect against this progression into apoptosis, but dexamethasone and sodium butyrate could...
متن کاملNeutrophil NADPH oxidase is reduced at the Anaplasma phagocytophilum phagosome.
The intracellular organism Anaplasma phagocytophilum causes human granulocytic ehrlichiosis and specifically infects and multiplies in neutrophilic granulocytes. Previous reports have suggested that, for its survival, this bacterium suppresses the neutrophil respiratory burst. To investigate the mechanism of survival, we first assessed the kinetics of A. phagocytophilum entry into neutrophils b...
متن کاملTransformation of Anaplasma phagocytophilum
BACKGROUND Tick-borne pathogens cause emerging zoonoses, and include fastidious organisms such as Anaplasma phagocytophilum. Because of their obligate intracellular nature, methods for mutagenesis and transformation have not been available. RESULTS To facilitate genetic manipulation, we transformed A. phagocytophilum (Ap) to express a green fluorescent protein (GFP) with the Himar1 transposas...
متن کاملAnaplasma phagocytophilum, Sardinia, Italy
1. McQuiston JH, Childs JE. Q fever in humans and animals in the United States. Vector Borne Zoonotic Dis. 2002;2: 179–91. 2. Maurin M, Raoult D. Q fever. Clin Microbiol Rev. 1999;12:518–53. 3. Stoker MGP, Marmion BP. The spread of Q fever from animals to man: the natural history of a rickettsial disease. Bull World Health Organ. 1955;13:781–806. 4. Spicer AJ. Military significance of Q fever: ...
متن کاملInfection with Anaplasma phagocytophilum induces multilineage alterations in hematopoietic progenitor cells and peripheral blood cells.
Infection with Anaplasma phagocytophilum, a gram-negative, lipopolysaccharide (LPS)-negative, obligate intracellular bacterium, results in multiple peripheral blood cytopenias. We hypothesized that infection with this organism would result in decreased bone marrow (BM) function and shifts in hematopoietic progenitor cells (HPCs) and lineage-committed cells in a well-established murine model of ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2004
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.72.6.3680-3683.2004