Analyzing Association Mapping in Pedigree-Based GWAS Using a Penalized Multitrait Mixed Model
نویسندگان
چکیده
منابع مشابه
A penalized linear mixed model for genomic prediction using pedigree structures
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Misspecification in Mixed-Model-Based Association Analysis.
Additive genetic variance in natural populations is commonly estimated using mixed models, in which the covariance of the genetic effects is modeled by a genetic similarity matrix derived from a dense set of markers. An important but usually implicit assumption is that the presence of any nonadditive genetic effect increases only the residual variance and does not affect estimates of additive g...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2016
ISSN: 0741-0395
DOI: 10.1002/gepi.21975