Analysis of tissue factor positive microparticles
نویسندگان
چکیده
منابع مشابه
PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI.
Heparin-induced thrombocytopenia (HIT) is a potentially devastating form of drug-induced thrombocytopenia that occurs in patients receiving heparin for prevention or treatment of thrombosis. Patients with HIT develop autoantibodies to the platelet factor 4 (PF4)/heparin complex, which is termed the HIT Ab complex. Despite a decrease in the platelet count, the most feared complication of HIT is ...
متن کاملTissue factor-bearing microparticles and thrombus formation.
Blood microparticles are vesicular structures with a diameter of 100 to 1000 nm that are present in the blood of normal subjects and in patients with various diseases. These microparticles are derived from cells that circulate in the blood and cells associated with the blood vessel wall. Microparticle membranes retain the protein receptors of their parent cells and may retain RNAs and other cyt...
متن کاملTissue factor-positive microparticles in blood associated with coagulopathy in cancer.
Thromb Haemost 2007; 97: 9–10 Thrombotic events are the major complication in cancer patients, which contribute significantly to the patients’ morbidity and mortality. Upregulation of tissue factor (TF), the primary initiator of blood coagulation, on malignant tumors is associated with hypercoagulability, tumor angiogenesis and progression. Blood-borne TF is mostly present on the surface of cir...
متن کاملSickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes.
Blood microparticles (MPs) in sickle cell disease (SCD) are reportedly derived only from erythrocytes and platelets. Yet in SCD, endothelial cells and monocytes are activated and abnormally express tissue factor (TF). Thus, sickle blood might contain TF-positive MPs derived from these cells. With the use of flow cytometry to enumerate and characterize MPs, we found total MPs to be elevated in c...
متن کاملTumor-derived tissue factor-positive microparticles and venous thrombosis in cancer patients.
Patients with cancer have an increased risk for venous thrombosis. Interestingly, different cancer types have different rates of thrombosis, with pancreatic cancer having one of the highest rates. However, the mechanisms responsible for the increase in venous thrombosis in patients with cancer are not understood. Tissue factor (TF) is a transmembrane receptor and primary initiator of blood coag...
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ژورنال
عنوان ژورنال: Thrombosis Research
سال: 2010
ISSN: 0049-3848
DOI: 10.1016/j.thromres.2010.01.035