Analysis of Potential Risk Factors for Multidrug-Resistance at a Burn Unit

Background: Infections by multidrug-resistant (MDR) microorganisms are associated with increased morbidity and mortality in burn patients. This study aimed to analyze the evolution of MDR bacteria over a five-year period at Coimbra Burns Unit (CBU) Portugal, seeking assess possible associations specific presumed risk factors. Methods: The data obtained consisted identified present any microbiological sample from each patient (including blood, central venous catheter, urine, tracheal aspirate and/or wound exudate). Univariate models multivariate model were constructed for species that infected least 50 patients or had five more strains. Statistical hypothesis tests p-value less than 0.05 considered significant. Results: Of total 341 samples obtained, 107 MDR, corresponding 10 species. Globally, there was no significant variation frequency under analysis. Some factors trends some species, but none linked all them. Conclusions: risks development multifactorial, mainly longer hospital stays, use invasive devices inadequate antimicrobial treatment. However, influence these regarding bacterial is not straightforward may rely on individual characteristics, type treatment local prevalent flora. Due severity infections, continued surveillance aid rapid diagnostic prompt institution appropriate therapy crucial improving outcomes