Analysis of DNA adducts in rats exposed to pentachlorophenol

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Analysis of DNA adducts in rats exposed to pentachlorophenol.

Pentachlorophenol (PCP) is a widely used biocide that has been reported to be hepatocarcinogenic in mice. Its effects in rats are equivocal, but the liver clearly is not a target organ for carcinogenesis. The carcinogenic effects of PCP in mice may relate to reactive oxygen species generated during metabolism. PCP is known to increase the hydroxyl radical-derived DNA lesion, 8-oxodeoxyguanosine...

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ژورنال

عنوان ژورنال: Carcinogenesis

سال: 2002

ISSN: 1460-2180,0143-3334

DOI: 10.1093/carcin/23.2.365