Analysis of copy number variations at 15 schizophrenia-associated loci
نویسندگان
چکیده
منابع مشابه
Analysis of copy number variations at 15 schizophrenia-associated loci
BACKGROUND A number of copy number variants (CNVs) have been suggested as susceptibility factors for schizophrenia. For some of these the data remain equivocal, and the frequency in individuals with schizophrenia is uncertain. AIMS To determine the contribution of CNVs at 15 schizophrenia-associated loci (a) using a large new data-set of patients with schizophrenia (n = 6882) and controls (n ...
متن کاملSchizophrenia-associated Loci Analysis of Copy Number Variations at 15 Material Supplementary from Downloaded Analysis of Copy Number Variations at 15 Schizophrenia-associated Loci
Copy number variants (CNVs) are chromosomal rearrangements involving large segments of DNA (from 1000 and up to several million base pairs in length) that can be deleted, duplicated, inverted or translocated. A number of pathogenic CNVs are known to cause clinically recognisable syndromes, such as Williams–Beuren syndrome (WBS), Angelman/Prader–Willi syndrome (AS/PWS) and velocardiofacial syndr...
متن کاملNew Copy Number Variations in Schizophrenia
Genome-wide screenings for copy number variations (CNVs) in patients with schizophrenia have demonstrated the presence of several CNVs that increase the risk of developing the disease and a growing number of large rare CNVs; the contribution of these rare CNVs to schizophrenia remains unknown. Using Affymetrix 6.0 arrays, we undertook a systematic search for CNVs in 172 patients with schizophre...
متن کاملSystematic prioritization and integrative analysis of copy number variations in schizophrenia reveal key schizophrenia susceptibility genes.
Schizophrenia is a common mental disorder with high heritability and strong genetic heterogeneity. Common disease-common variants hypothesis predicts that schizophrenia is attributable in part to common genetic variants. However, recent studies have clearly demonstrated that copy number variations (CNVs) also play pivotal roles in schizophrenia susceptibility and explain a proportion of missing...
متن کاملPotential Value of Genomic Copy Number Variations in Schizophrenia
Schizophrenia is a devastating neuropsychiatric disorder affecting approximately 1% of the global population, and the disease has imposed a considerable burden on families and society. Although, the exact cause of schizophrenia remains unknown, several lines of scientific evidence have revealed that genetic variants are strongly correlated with the development and early onset of the disease. In...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 2014
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.bp.113.131052