Analysis of Aqueous Humor Cytokines in Exudative Age-related Macular Degeneration and Diabetic Macular Edema

Purpose: To investigate the cytokine concentrations of aqueous humor in patients with exudative age-related macular degeneration (AMD) and diabetic edema (DME).Methods: Fifty-seven subjects were included AMD, DME control groups, each group has 19 patients. Aqueous levels cytokines epidermal growth factor (EGF), vascular endothelial factor-C (VEGF-C), monocyte chemoattractant protein-1 (MCP-1), hepatocyte (HGF), interleukin (IL)-3, IL-8, IL-6, IL-12p40, intercellular adhesion molecule 1 (ICAM-1) investigated groups. Kruskal-Wallis test Mann-Whitney U performed to compare concentrations.Results: EGF, VEGF-C, MCP-1, HGF, IL-3, IL-8 significantly higher AMD than (<i>p</i> = < 0.0001, 0.004, 0.015, 0.014) 0.005). In comparison between EGF was 0.001).Conclusions: Various increased DME. particular, showed a level