Analysis of 16 coils over 50 MRI-derived head models in transcranial magnetic stimulation

Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique investigated for the treatment of various neuropsychiatric disorders such as major depressive disorder and obsessive-compulsive disorder. Coil design analysis has been popular topic in TMS studies, primarily coil geometry significantly affects induced electric field ( $E$ -field) distribution. In this work, we compare distribution -field 16 different coils by finite element analysis. The are positioned at two head locations: vertex dorsolateral prefrontal cortex (DLPFC). Due to geometry, only nine DLPFC. Notably, authors use 50 heterogeneous models derived from MRI scans healthy patients As result, sensitivity intensity focality anatomical variations investigated. maximum brain -Max brain), volume exposed with least half notation="LaTeX">$V$ -Half) were metrics used assess -field. It was observed that some high highly sensitive variations. Other exhibited lower same time. For DLPFC, less variability when compared location. This study provides an understanding effect variation on during TMS.