Analgesic effect of intravenous versus intraperitoneal dexmedetomidine as an adjuvant to intraperitoneal bupivacaine (0.125%) in laparoscopic cholecystectomy: a randomized, double blind, interventional study

Background and Aims: Laparoscopic cholecystectomy has emerged as a gold standard technique for gall bladder stones. The aim of the present study was to compare analgesic effect intravenous (IV) vs intraperitoneal (IP) dexmedetomidine an adjuvant bupivacaine in laparoscopy. Methods: A prospective, randomized, double blind, interventional conducted on 100 patients undergoing laparoscopic where they were divided into following 2 groups: Group A: Patients received IV 1µg/kg diluted 30 ml with normal saline over 10 min 40 0.125% IP after removal bladder. B: primacy outcome noted difference mean duration need first rescue analgesia. total consumption 24hours recorded compared between two groups. Results: Both groups comparable terms demographic profile intraoperative hemodynamic parameters no statistical difference. Comparison time requirement showed statistically significant results unpaired t test analgesia 151.80 ± 76.624. B 94.80min 21.499. 24 hours 136.64 31.251 144.12 21.49. Conclusion: In our we concluded that dexmetomidine provided superior when used Bupivacaine intraperitoneally.