Analgesic Activity of Morphine Suppository in Rats
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چکیده
منابع مشابه
Gabapentin increases analgesic effect of morphine in male rats
The clinical usefulness of morphine for treatment of chronic pain is limited by development of tolerance. So many authors have proposed the co-administration of other drugs. This study was performed to evaluate the role of gabapentin on analgesic effect of morphine. Four groups of male rats (220-250 g) were examined for time latency using tail flick test: control, morphine (M), gabapentin (GB),...
متن کاملGabapentin increases analgesic effect of morphine in male rats
The clinical usefulness of morphine for treatment of chronic pain is limited by development of tolerance. So many authors have proposed the co-administration of other drugs. This study was performed to evaluate the role of gabapentin on analgesic effect of morphine. Four groups of male rats (220-250 g) were examined for time latency using tail flick test: control, morphine (M), gabapentin (GB),...
متن کاملIntrathecal administration of epinephrine inhibits and reverses analgesic tolerance to analgesic effect of morphine in rats
Introduction: Several researches have reported that stress is able to inhibit the development of morphine tolerance via activating of Hypothalamic-Pituitary-Adrenal (HPA) axis. In the present study we tried to examine the effect of epinephrine, the product of adrenal medulla, on the development of morphine tolerance. Methods: Analgesic tolerance was induced by intrathecal (i.t.) injection of...
متن کاملAnalgesic efficacy of ketorolac and morphine in neonatal rats.
Ketorolac is a potent nonsteroidal antiinflammatory drug (NSAID). In adult humans and animals, its analgesic efficacy can be comparable to opiates. However, it has not been studied in neonatal animals. We conducted a blinded, controlled study comparing the effects of ketorolac and morphine in neonatal rats using the formalin model. Animals were given intraperitoneal (i.p.) injections of ketorol...
متن کاملEffect of Cuneiformis Nucleus Inactivation by Lidocaine Microinjection on the Analgesic Response of Morphine in Rats
The present study was performed to evaluate the analgesic effect of morphine microinjection into the cuneiformis nucleus (CnF) and the effect of inactivation of this area by lidocaine on pain modulation. Rats were anaesthetized by thiopental (45-60 mg/kg/i.p.) and placed in a stereotaxic instrument, and then a guide cannula was implanted just one mm above the CnF. Following surgery and recovery...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1990
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.110.5_349