An uncommon cause of severe polycystic ovary syndrome (PCOS)
نویسندگان
چکیده
IntroductionPolycystic ovaries in adolescent girls with irregular periods are most commonly associated insulin resistance and hypergonadism within the PCOS. In rare instances, these findings may be caused by other underlying disorders (1,2).Case presentationA 16-year-old girl was admitted to endocrinology department due polyuria, polydipsia, weight loss. Irregular presented at age of 12, hirsutism since 14 years age. Clinical examination revealed (Ferriman-Gallwey score 22), severe acanthosis nigricans. BMI fat mass distribution were normal. Baseline investigations elevated glucose levels (6.9 mmol/L), HbA1c (7.8%), glycosuria.Further investigation showed impaired tolerance up 488 mIU/L, HOMA-IR 41, high testosterone (4.6 nmol/L), androstenedione, DHEAS, anti-Mullerian hormone (75.3 ng/ml). Antibodies usually present type 1 diabetes mellitus (T1DM): GAD IA2, TPO, as well ANA antibodies, negative. Pelvic ultrasound detected polycystic ovaries.Because hyperandrogenism uncommon adolescents normal BMI, molecular genetic testing conducted. Heterozygous likely pathogenic deletion exons 15 22 INSR gene detected, confirming diagnosis Type A syndrome.Oral metformin therapy oral contraceptive pills introduced.ConclusionMisdiagnosis is when covered signs or symptoms syndrome, such PCOS.Written informed consent for anonymized use medical information purposes writing publishing a case report has been obtained from both her parents. Polycystic (1,2). glycosuria. Further ovaries. Because syndrome. Oral introduced. Misdiagnosis
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ژورنال
عنوان ژورنال: Journal of Pediatric and Adolescent Gynecology
سال: 2023
ISSN: ['1873-4332', '1083-3188']
DOI: https://doi.org/10.1016/j.jpag.2023.01.210