An S6:S18 complex inhibits translation ofE. coli rpsF
نویسندگان
چکیده
منابع مشابه
A Strict Border for the Decidability ofE {
During the execution of functional logic programs, E{unii-cation problems have to be solved quite frequently, where the underlying equational theory is induced by recursive functions. But, what about the decidability of those E{uniication problems? Up to now, there does not exist a concrete answer to this question. In this paper, we answer this question by drawing and verifying a strict border ...
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2-methoxyestradiol (2ME2), an estradiol metabolite with antiproliferative and antiangiogenic activities, is in phase I/II clinical trials for breast cancer. 2ME2 inhibits microtubule polymerization and causes cells to arrest in G2-M. The purpose of this study was to further elucidate the molecular mechanism of 2ME2. MDA-MB-435 breast cancer cells were treated with 2ME2 (2 micromol/L) or vehicle...
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The 70S ribosome and its complement of factors required for initiation of translation in E. coli were purified separately and reassembled in vitro with GDPNP, producing a stable initiation complex (IC) stalled after 70S assembly. We have obtained a cryo-EM reconstruction of the IC showing IF2*GDPNP at the intersubunit cleft of the 70S ribosome. IF2*GDPNP contacts the 30S and 50S subunits as wel...
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Formation of the 30S initiation complex (30S IC) is an important checkpoint in regulation of gene expression. The selection of mRNA, correct start codon, and the initiator fMet-tRNA(fMet) requires the presence of three initiation factors (IF1, IF2, IF3) of which IF3 and IF1 control the fidelity of the process, while IF2 recruits fMet-tRNA(fMet). Here we present a cryo-EM reconstruction of the c...
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ژورنال
عنوان ژورنال: RNA
سال: 2015
ISSN: 1355-8382,1469-9001
DOI: 10.1261/rna.049544.115