An Oxidative Stress Marker in Pediatric Migraine Patients: Dynamic Thiol-Disulfide Homeostasis

Objective: Migraine is a common disease in childhood. Oxidative stress has been implicated the pathogenesis of migraine. Dynamic thiol/disulfide homeostasis proven to be marker oxidative stress. We aimed investigate correlation between migraine and dynamic homeostasis. Material Methods: A total 141 children (71 migrain 70 controls) were included. The serum thiol, native disulfide levels measured ratios disulfide/native disulfide/total thiol thiol/total compared patients healthy during attack-free period. Results: Native ratio significantly lower group than control (p=0.022, p=0.005, respectively); whereas levels, higher (p=0.039, p=0.022, p=0.005 respectively). Conclusion: Our results demonstrate that there an ongoing process pediatric migraineurs even This result may shed light on further studies analyzing changes oxidant-antioxidant balance attack aura phase support presence importance