An Optimized Herbal Formula Reverses the Hepatotoxicity Induced by Acetaminophen

Objectives: In this present study the hepatoprotective effect of an optimized herbal formula (HF) was appraised against paracetamol induced liver damage in rats. Methods: In vitro antioxidant activity HF evaluated by ABTS radical scavenging assay. The (100, 200 and 400 mg/kg b.w) assessed Serum enzymatic levels serum glutamate oxaloacetate transaminase (AST), pyruvate (ALT), alkaline phosphatase (ALP) Gamma-glutamyltransferase (γ-GT) were along with estimation catalase (CAT), superoxide dismutase (SOD), Glutathione (GSH) TBARS tissues. Lipid profile also examined. Furthermore, histopathological examination sections performed to approve advocate induction hepatotoxicity as well effectiveness. Results: showed robust in vitro antioxidant activities terms scavenging. reinstated significantly raised AST, ALT, ALP γ-GT a dose dependent manner. lipid found be stabilized. remarks did further establish biochemical indications hepatoprotection. Elevated level reduced tissues reinforce actions. Conclusion: outcomes evidently unveil efficacy justify;">Key words: Antioxidant, Hepatoprotective, Herbal formula, Paracetamol, Silymarin.