An open quantum systems approach to proton tunnelling in DNA

Abstract One of the most important topics in molecular biology is genetic stability DNA. threat to this proton transfer along hydrogen bonds DNA that could lead tautomerisation, hence creating point mutations. We present a theoretical analysis between Guanine-Cytosine (G-C) nucleotide, which includes an accurate model structure base pairs, quantum dynamics bond proton, and influence decoherent dissipative cellular environment. determine tunnelling contribution rate several orders magnitude larger than classical over-the-barrier hopping. Due significance even at biological temperatures, we find canonical tautomeric forms G-C inter-convert over timescales far shorter ones thermal equilibrium rapidly reached. Furthermore, large occupation probability 1.73 × 10 ?4 , suggesting such may well play more role mutation has hitherto been suggested. Our results have far-reaching consequences for current models