An Investigation Into LOXL1 Variants in Black South African Individuals With Exfoliation Syndrome
نویسندگان
چکیده
منابع مشابه
An investigation into LOXL1 variants in black South African individuals with exfoliation syndrome.
OBJECTIVE To investigate the association between 2 lysyl oxidase-like 1 (LOXL1) polymorphisms, rs1048661 (R141L) and rs3825942 (G153D), and exfoliation syndrome (XFS) in black South African individuals. METHODS A total of 43 black patients with XFS and 47 ethnically matched controls were recruited for genetic analysis. Samples were analyzed for presence of the LOXL1-R141L and G153D variants u...
متن کاملMajor LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population
PURPOSE To investigate whether variants in the lysyl oxidase-like 1 (LOXL1) gene are associated with exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) in an ancestral population from South Africa. METHODS Black South African subjects with XFG, POAG, and age matched unaffected controls were recruited from the St. John Eye Hospital in Soweto, Johannesburg, South Africa, using st...
متن کاملExfoliation syndrome in black South Africans.
BACKGROUND Data on exfoliation syndrome (XFS) in Africans are scarce. OBJECTIVE To determine the prevalence and clinical features of XFS among black South Africans. DESIGN Random cross-sectional samples of the black population aged 40 years or older from 2 districts in South Africa: Hlabisa, in northern KwaZulu-Natal Province, and Temba, North West Province. METHODS Standardized examinati...
متن کاملLOXL1 gene sequence variants and vascular disease in exfoliation syndrome and exfoliative glaucoma.
PURPOSE To investigate whether the single nucleotide polymorphisms (SNPs) of the LOXL1 gene associated with exfoliation syndrome (XFS) and exfoliative glaucoma (XFG) are different in XFS/XFG patients with and without cardiovascular disease (CVD); and to compare the allele frequencies in XFS/XFG with those in ischemic cerebrovascular disease (stroke), in the Hungarian population. METHODS G153D...
متن کاملEvaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma
PURPOSE To evaluate genetic susceptibility of lysyl oxidase-like 1 (LOXL1) gene polymorphisms to exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in a case-control cohort of American and European patients. METHODS DNA from a total of 620 individuals including 287 exfoliation patients and 333 healthy control subjects were extracted by standard methods. Three single nucleotide polymorp...
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ژورنال
عنوان ژورنال: Archives of Ophthalmology
سال: 2011
ISSN: 0003-9950
DOI: 10.1001/archophthalmol.2010.349