An interesting case of reversible metabolic myopathy: Tumor induced osteomalacia

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Tumor-induced osteomalacia mimics osteoporosis: case report

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic disorder in which a neoplasm causes systemic bone demineralization. Most cases are benign, but malignant neoplasms have been reported. The prognosis is good if diagnosis is made early and treatment is adequate. We present the case of a previously healthy 40-year-old man who presented with low back pain for the previous year. The initial ...

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Tumor-induced osteomalacia.

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, a defect in vitamin D metabolism, and osteomalacia. This debilitating disorder is illustrated by the clinical presentation of a 55-year-old woman with progressive fatigue, weakness, and muscle and bone pain with fractures. After a protracted clinical course and exte...

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Tumor-induced osteomalacia

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome clinically characterized by bone pain, fractures and muscle weakness. It is caused by tumoral overproduction of fibroblast growth factor 23 (FGF23) that acts primarily at the proximal renal tubule, decreasing phosphate reabsorption and 1α-hydroxylation of 25 hydroxyvitamin D, thus producing hypophosphatemia and osteomalacia. Les...

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A case report of phosphaturic mesenchymal tumor-induced osteomalacia

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ژورنال

عنوان ژورنال: Annals of Indian Academy of Neurology

سال: 2014

ISSN: 0972-2327

DOI: 10.4103/0972-2327.132657