An Interesting Case of Proteinuria: AL Amyloidosis

نویسندگان

چکیده

Light-chain (AL) amyloidosis is the most common form of systemic and associated with an underlying plasma cell dyscrasia. The disease often difficult to recognise because its broad range manifestations what are vague symptoms. clinical syndromes at presentation include nephrotic-range proteinuria or without renal dysfunction, hepatomegaly, congestive heart failure autonomic sensory neuropathy. Recent diagnostic prognostic advances serum free light-chain assay, cardiac magnetic resonance imaging serologic biomarkers. Treatment strategies that have evolved during past decade prolonging survival preserving organ function in patients this disease. This review outlines approaches diagnosis, assessment severity treatment AL amyloidosis. We describe a case 54--year-old male patient monoclonal gammopathy

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AL Amyloidosis

UNLABELLED DEFINITION OF THE DISEASE: AL amyloidosis results from extra-cellular deposition of fibril-forming monoclonal immunoglobulin (Ig) light chains (LC) (most commonly of lambda isotype) usually secreted by a small plasma cell clone. Most patients have evidence of isolated monoclonal gammopathy or smoldering myeloma, and the occurrence of AL amyloidosis in patients with symptomatic multip...

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ژورنال

عنوان ژورنال: Vidarbha journal of internal medicine

سال: 2022

ISSN: ['0976-4356']

DOI: https://doi.org/10.25259/vjim_16_2021