An integrative approach uncovers transcriptome‐wide determinants of mRNA stability regulation in Saccharomyces cerevisiae

mRNA degradation rate is one of the key stages gene expression regulation in eukaryotic cells. To date, intertwined processes post-transcriptional control have been widely investigated, but focused rather on examination mechanisms controlling stability particular protein-coding transcripts. Currently, a wealth information from structural, biochemical, and high-throughput studies makes it tempting to define general rules governing that could be considered as versatile valid genome-wide scale. Basu et al. analyzed multiple experimental computational data Saccharomyces cerevisiae half-lives well secondary structures protein-binding sites within transcripts, collated with available ribonucleases, is, enzymes responsible for degradation. This approach allowed conclude how features such lengths unstructured terminal or internal regions sequestration into ribonucleoprotein complexes impact transcripts genome-scale principles yeast.