An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets
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چکیده
منابع مشابه
An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets.
The platelet P2Y(12) purinoceptor (P2Y(12)R), which plays a crucial role in hemostasis, undergoes internalization and subsequent recycling to maintain receptor responsiveness, processes that are essential for normal platelet function. Here, we observe that P2Y(12)R function is compromised after deletion or mutation of the 4 amino acids at the extreme C-terminus of this receptor (ETPM), a putati...
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1School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom; 2Haemostasis Research Group, Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom; 3Angelo Division of Haematology and Transfusion Medicine, L. Sacco University Hospital, Department of Internal Medicine, Università degli Studi, Milan, Italy; 4Angelo Bianchi Bonomi Haemophi...
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ژورنال
عنوان ژورنال: Blood
سال: 2011
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2011-02-336826