An Insulin-Sensitizing Thiazolidinedione, Which Minimally Activates PPARγ, Does Not Cause Bone Loss
نویسندگان
چکیده
منابع مشابه
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Thiazolidinedione (TZD) compounds are widely used as oral hypoglycemic agents. Herein, we provide evidence showing that troglitazone, one of the TZD compounds, is able to prevent glomerular dysfunction in diabetic rats through a novel mechanism independent of its insulin-sensitizing action. We examined the effect of troglitazone on functional and biochemical parameters of glomeruli in streptozo...
متن کاملThiazolidinedione use and bone loss in older diabetic adults.
CONTEXT Activation of peroxisome proliferator-activated receptor-gamma by thiazolidinediones (TZDs) results in lower bone mass in mice. OBJECTIVE The objective of the study was to determine whether TZD use is associated with changes in bone mineral density (BMD) in older adults with type 2 diabetes. DESIGN We analyzed 4-yr follow-up data from the Health, Aging, and Body Composition observat...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2015
ISSN: 0884-0431
DOI: 10.1002/jbmr.2364