An In Vitro Study of Chitosan-Coated Bovine Pericardium as a Dural Substitute Candidate

Defects in the dura matter can be caused by head injury, and many cases require neurosurgeons to use artificial matter. Bovine pericardium is an option due its abundant availability, adjustable size characteristics, because it has more collagen than porcine or equine pericardia. Nevertheless, drawback of bovine that a higher inflammatory effect other synthetic matters. Chitosan been shown have strong anti-inflammatory good tensile strength; thus, idea was formulated chitosan as coating for pericardium. This study used decellularized pericardial membranes with 0.5% sodium dodecyl sulphate coatings containing at concentrations 0.25%, 0.5%, 0.75%, 1%. An FTIR test showed presence C=N functional group pericardium–chitosan bond. Morphological tests 0.25% standard pore sizes. The highest strength percentage membrane concentration degradation rate observed on 7th 14th days 0.75% 1% concentrations, lowest swelling ratio concentration. level cell viability found chitosan. considered optimal sample