An <i>α</i>-Sophoradiol Glycoside from the Root Wood of <i>Erythrina senegalensis</i> DC. (Fabaceae) with <i>α</i>-Amylase and <i>α</i>-Glucosidase Inhibitory Potential

Phytochemical study of the roots Erythrina senegalensis led to isolation a new α-sophoradiol glycoside, erythrinoside (1), together with four known compounds, lupeol (2), (3), isoneorautenol (4) and D-mannitol (5). The structures compounds were elucidated using spectroscopic data including 1D 2D NMR, mass spectrometry by comparison made some reported previously; samples (extracts compounds) also subjected antidiabetic assay. Erythrinoside exhibited good α-amylase inhibitory potential 54.6% 53.3%, respectively, compared acarbose (72.5%) at 400 µg/mL. With α-glucosidase, all showed promising inhibition percentages above 50% 200 In α-glucosidase assay, ethyl acetate extract (65.5%), methanol (72.1%), (63.3%) (66.0%) had percentage inhibitions closer that (69.0%) (IC 50 = 81.2 ± 0.9 µg/mL) was more active than 94.5 0.7 µg.mL) in indicates E. extracts could be used manage diabetic conditions.