An Experimental Pharmacokinetic Computer Program to Predict Potential Drug-Drug Interactions

Potential Drug Interactions in War-Injured Veterans

Drug-drug interaction (DDI) is one of the most important problems in the treatment of patients suffering from different chronic intractable diseases. The war-injured veterans are one of the groups that are prone to chronic refractory diseases. This investigation was conducted on war-injured veterans treated in a multi-disciplinary clinic in Tehran. Using Poisson model, a total of 150 patients w...

Beneficial Pharmacokinetic Drug Interactions

A drug interaction occurs when the usual effects of a drug are enhanced or diminished by another drug being taken by the patient. In most cases, these interactions are unintentional and come to the attention of clinicians due to a therapeutic failure or adverse event that is undesirable. Polypharmacy and drug interactions are common particularly among seniors. A survey of elderly individuals li...

Exposure to potential CYP450 pharmacokinetic drug-drug interactions among osteoarthritis patients: incremental risk of multiple prescriptions.

Patients taking more than one drug metabolized through the cytochrome P450 (CYP450) enzyme system experience a drug-drug exposure (DDE), which puts them at risk for a potential pharmacokinetic drug-drug interaction (DDI), defined as two or more drugs interacting in such a way that the effectiveness and/or toxicity of one or all drugs are changed. Any patient subjected to a DDE is at risk for a ...

Pharmacokinetic Drug Interactions of Azoles

Pharmacokinetic drug interactions of macrolides.

The macrolide antibiotics include natural members, prodrugs and semisynthetic derivatives. These drugs are indicated in a variety of infections and are often combined with other drug therapies, thus creating the potential for pharmacokinetic interactions. Macrolides can both inhibit drug metabolism in the liver by complex formation and inactivation of microsomal drug oxidising enzymes and also ...