AN EXPEDIENT APPROACH TO TREAT ASTHMA THROUGH NON-STEROIDAL, NATURAL TRANSFEROSOMES AEROSOL SYSTEM
نویسندگان
چکیده
Asthma is the most common respiratory disease, affecting an estimated 262 million people and resulting in 461,000 fatalities 2019. The treatment available on market, but it quite expensive, also has serious adverse effects due to high concentration of steroids medicine. If given effectively, curcumin, formononetin, matrine’s anti-inflammatory properties can play a significant role treatment. To improve chemical stability therapeutic potential these active pharmaceutical ingredients (APIs) tract, transferosomes system was designed, which encapsulates APIs inside its vesicular structure delivers them selectively inflamed cells. DPPC layer will allow for efficient penetration, whereas Tween-80 aid deformability lower interfacial tension, small Z-average diameter, allowing penetration between layers APIs’ at alkaline pH (7.6) ensured by nano-vesicular structure, significantly increases cellular antioxidant activity ferric reducing power values. On RAW264.7 cell line, formulation be tested activity. Nuclear factor kappa B, tumor necrosis factor, interleukin (IL)-1, IL-2, IL-6, IL-8, IL-12, nitric oxide, cyclooxygenase-2 are all reduced matrine. They have inhibitory effect MAPK signaling pathway, preventing extracellular signal-regulated kinase, c-Jun N-terminal p38 from causing inflammation. This effectively treat asthma without use steroids, no effects, inexpensive.
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ژورنال
عنوان ژورنال: Innovare journal of medical sciences
سال: 2022
ISSN: ['2321-4406']
DOI: https://doi.org/10.22159/ijms.2022.v10i6.46451