An ERCC1 splicing variant involving the 5′-UTR of the mRNA may have a transcriptional modulatory function
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چکیده
منابع مشابه
Identification and Characterization of a Splicing Variant in the 5′ UTR of the Human TLR5 Gene
Toll-like receptors (TLRs) are essential components of the innate immune system. TLR5 is the receptor for flagellin, the principal protein component of bacterial flagella. The TLR5 gene has 6 exons. In an RT-PCR analysis, we found long TLR5 transcripts, in addition to those of the expected size (short TLR5 transcripts). A sequence analysis revealed that the long TLR5 transcripts contain a new e...
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15 صفحه اولSerine-arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing.
Two distinct functions have been proposed for the serine-arginine (SR)-rich family of splicing factors. First, SR proteins are essential splicing factors and are thought to function by mediating protein-protein interactions within the intron during spliceosome assembly. Second, SR proteins bind to exonic enhancer sequences and recruit spliceosome components to adjacent introns. The latter activ...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2001
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1204977