An Epigenome-Wide Association Study of Total Serum Immunoglobulin E Concentration
نویسندگان
چکیده
منابع مشابه
Epigenome-Wide Association Study of Tic Disorders.
Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-r...
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Wellbeing (WB) is a major topic of research across several scientific disciplines, partly driven by its strong association with psychological and mental health. Twin-family studies have found that both genotype and environment play an important role in explaining the variance in WB. Epigenetic mechanisms, such as DNA methylation, regulate gene expression, and may mediate genetic and environment...
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Previously, we reported strong influences of genetic variants on metabolic phenotypes, some of them with clinical relevance. Here, we hypothesize that DNA methylation may have an important and potentially independent effect on human metabolism. To test this hypothesis, we conducted what is to the best of our knowledge the first epigenome-wide association study (EWAS) between DNA methylation and...
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ژورنال
عنوان ژورنال: PEDIATRICS
سال: 2015
ISSN: 0031-4005,1098-4275
DOI: 10.1542/peds.2015-2776yyy