An Enzyme System from Mitochondria Catalyzing Adenosine Diphosphate-Adenosine Triphosphate and Orthophosphate-Adenosine Triphosphate Exchange Reactions
نویسندگان
چکیده
منابع مشابه
The adenosine triphosphate-adenosine diphosphate exchange reaction of oxidative phosphorylation.
Previous reports from this laboratory have demonstrated that the ATP-Pi32 1 exchange reaction (1) and the dinitrophenolstimulated ATPase activity (2) of mitochondrial subfragments (3-9) are reflections of intermediate enzymatic steps in the complex sequence of reactions (1, 3) in which phosphorylation of ADP is coupled to electron transport in the respiratory chain. This communication concerns ...
متن کاملThe adenosine triphosphate-adenosine diphosphate exchange reaction of intact rat liver mitochondria.
Studies of the adenosine triphosphate-adcnosine diphosphate exchange reaction of phosphorylating submitochondrial particles first described by Cooper and Lehninger (l), and subsequently studied in detail by Bronk and Kielley (2), and Wadkins and Lehninger (3) have provided evidence that this exchange reaction is a manifestation of the terminal step of oxidative phosphorylation in which ADP reac...
متن کاملThe Effects of Histones and Other Polycations on Cellular Energetics. Ii. Adenosine Triphosphatase and Adenosine Diphosphate-adenosine Triphosphate Exchange Reactions of Mitochondria.
Previous studies in this laboratory have revealed inhibitory effects of various basic compounds on adenosine triphosphat,ase systems associated with active cation transport (l-7). During the course of preliminary investigation of a mitochondrial ATPase preparation (8), it was found t’hat very low concentrations of highly purified histone fractions increased ATPase activity in a manner similar t...
متن کاملAdenosine triphosphate inhibition in myosin adenosine triphosphate systems.
Factors affecting inhibition of myosin ATPase by ATP, such as concentration of the enzyme, of ATP, and of the divalent metals, calcium and magnesium, have been studied and the results are reported here. Experiments were carried out under conditions in which no known magnesium effects occurred, so that only the effect of calcium on the nucleoside triphosphatase activity of myosin A could be qual...
متن کاملEffect of potassium on sodium-dependent adenosine diphosphate-adenosine triphosphate exchange activity in kidney microsomes.
Maximal activation of a Na+-dependent adenosine diphosphate-adenosine triphosphate exchange reaction mediated by kidney microsomes was achieved at 0.1 mu and 0.4 mu Mg++ in the presence of 1.5 mM and 32 mM Na+, respectively. K+ inhibited the Na+-dependent exchange rate when lower concentrations of Na+ and Mg++ were used and stimulated it in the presence of 0.4 mM Mg++ and 32 mM Na+. The inhibit...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1959
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)69725-x