An enzyme preparation inactivating all penicillins and cephalosporins
نویسندگان
چکیده
منابع مشابه
Penicillins and cephalosporins.
Resemblances and differences between the penicillins (I) and cephalosporins (II) are considered from a chemical and biochemical point of view.
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The discovery of penicillinase-resistant penicillins is an important landmark in the history of antibacterial chemotherapy. Methicillin came into clinical use in 1960, and its value in the treatment of penicillin-resistant staphylococcal infection is now well established. The same is true of the isoxazolyl penicillins, oxacillin and cloxacillin, which came on to the scenes about a year later. N...
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In 1944 medical personnel in London was scattered and communications were difficult, but a meeting at the Royal Society of Medicine in November of that year was one of the most crowded ever held there. Such an audience could then have been attracted by only one subject, penicillin, which at that time was proving its worth in the treatment of battle casualties. Of the opening speakers, Fleming i...
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The microiodometric assay of Novick for penicillinase was adapted to the Technicon Autoanalyzer system. With this automated method, it is possible to analyze almost 60 samples per hr. Two different procedures are described: in the first, the samples were incubated with substrate in the machine under standardized conditions; in the second, samples were incubated outside the Autoanalyzer and assa...
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Heteroresistance to antimicrobial agents may affect susceptibility test results and therapeutic success. In this study, we investigated heteroresistance to cephalosporins and penicillins in Acinetobacter baumannii, a major pathogen causing nosocomial infections. Two A. baumannii isolates exhibited heteroresistance to ampicillin-sulbactam, ticarcillin-clavulanic acid, cefepime, and cefpirome, sh...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1973
ISSN: 0021-9746
DOI: 10.1136/jcp.26.8.596