An early imbalance of interleukin 12 influences the adjuvant effect of mannoproteins of Cryptococcus neoformans

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Early induction of interleukin-12 by human monocytes exposed to Cryptococcus neoformans mannoproteins.

Interleukin-12 (IL-12) production by human monocytes stimulated with mannoproteins (MPs) of Cryptococcus neoformans was investigated. The results reported show that secreted or cell-associated MPs induce an early and significant production of IL-12. MPs show different capabilities to quantitatively affect IL-12 production; MP2, an 8. 2-kDa MP purified from the culture supernatant of C. neoforma...

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ژورنال

عنوان ژورنال: Cellular Microbiology

سال: 2004

ISSN: 1462-5814,1462-5822

DOI: 10.1111/j.1462-5822.2004.00411.x