An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians.
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چکیده
منابع مشابه
An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians.
Type 2 diabetes mellitus is a common chronic disease that is thought to have a substantial genetic basis. Identification of the genes responsible has been hampered by the complex nature of the syndrome. Abnormalities in insulin secretion and insulin action predict the development of type 2 diabetes and are, themselves, highly heritable traits. Since fewer genes may contribute to these precursor...
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A genome-wide linkage study was analyzed to identify loci that influence serum lipid concentrations in Pima Indians. Linkage analyses were conducted for total cholesterol measured in 998 siblings from 292 nuclear families, for total triglycerides in 547 siblings from 188 families, and for high density lipoprotein (HDL) cholesterol in 590 siblings from 201 families. Genotypes were generated for ...
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Genetic loci influencing the long-term levels and trends of blood pressure over time were investigated using 775 white siblings, ages 13 to 43 years, enrolled in the Bogalusa Heart Study, and 357 microsatellite markers on the 22 autosomal chromosomes. Subjects had been examined serially 2 to 12 times with 4365 serial observations over an average of 22 years from childhood to adulthood. Total an...
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much better for the author to have selected fewer topics for inclusion in the book, and to have given each one a more thorough treatment. Other subjects which are scantily covered include evidence for a myopia gene, existence of an alcoholism gene, genetic transmission of psychotic tendency, relation of creativity to the schizophrenia gene, and inherited personality and creative aptitude. As ca...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1998
ISSN: 0021-9738
DOI: 10.1172/jci1850