An Alternative Excipient from Vegetable Source for Oral Drug Dosage Forms to Regulate Drug Delivery

Abstract: Introduction: Tablet is the preferred drug dosage form. Cellulose fiber (Micro Crystalline Cellulose) major excipient used. For chronic diseases, frequent required resulting in cumulative load and tachyphylaxis due to drug. We intent invent excipients from vegetable sources mitigate above challenges reduce as sufferers (Diabetes mellitus) requires lifelong treatment. Aims Objectives: To develop an Brassica oleracea Vigna radiata sprouting which can regulate delivery, avoid led toxicity tachyphylaxis. Materials Methods: Alkali acid based depolymerization method was followed cellulose fibers were studied for safety, physical, chemical molecular parameters. With developed two drugs formulated using Active Pharmaceutical Ingredient- Metformin Miglitol. Efficacy assayed cell lines-Neuroblastoma, Kidney HK-2, L6 Myoblasts, 3T3-L1 Preadipocytes, INS-1 HEPG 2 hepatocytes compared with conventional micro crystalline cellulose- formulations. Results: Characterization of done comparison cellulose, invented had long fibers, higher bulk density, flow, even particle size cellulose. Dissolution disintegration slow Miglitol showed quick release excipient. Therapeutic effect both excipient-based by culture assay. Both did not show mutagenic effect. Conclusion: slows metformin; may dosage, tachyphylaxis, rapid, compliment metformin therapy. Keywords: Herbal excipients, Microcrystalline Tachyphylaxis, Vegetable source excipient, oleracea, radiata, Metformin,