An Active Morphine Glucuronide Responsible for Morphine Analgesia.
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients
BACKGROUND AND OBJECTIVE Morphine dosing can be challenging in terminally ill adult patients due to the heterogeneous nature of the population and the difficulty of accurately assessing pain during sedation. To determine the pharmacokinetics of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) in this population, and to find clinically relevant parameters for dose individu...
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INTRODUCTION Obesity is associated with many pathophysiological changes that may result in altered drug metabolism. The aim of this study is to investigate the influence of obesity on the pharmacokinetics of morphine, morphine-3-glucuronide (M3G), and morphine-6-glucuronide (M6G) through a combined analysis in morbidly obese patients and non-obese healthy volunteers. METHODS In this analysis,...
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Macrophages are abundant in the tumor microenvironment where they adopt a pro-tumor phenotype following alternative polarization induced by paracrine factors from cancer and stromal cells. In contrast, classically activated macrophages have tumoricidal activities, such that the polarization of tumor-associated macrophages has become a novel therapeutic target. Toll-like receptor 4 engagement pr...
متن کاملRelative contribution of morphine and morphine-6-glucuronide to the analgesic effect after morphine administration.
Editor—We thank Dahan and Lotsch for their interest in our review and their valuable comments to the discussion about the role of morphine-6glucuronide (M6G), for the analgesic effect after morphine administration. Because morphine is used worldwide as the potent standard analgesic drug, with the formation of an even more potent metaboliteM6G, it is important to elucidate the relative contribut...
متن کاملMorphine and morphine-glucuronide concentrations in plasma and CSF during long-term administration of oral morphine.
Concentrations of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) were measured by h.p.l.c. in plasma and cerebrospinal fluid (CSF) samples from 16 patients with cancer receiving oral (controlled-release) morphine. There was a close correlation between plasma and CSF morphine concentrations (r = 0.94, P = 0.0001) and both correlated with drug dosage (r = 0.61, P = 0.013 ...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 1999
ISSN: 0916-1139
DOI: 10.2133/dmpk.14.399