Amyotrophic lateral sclerosis and environmental factors
نویسندگان
چکیده
منابع مشابه
Potential Environmental Factors in Amyotrophic Lateral Sclerosis.
The causes of amyotrophic lateral sclerosis (ALS) are largely unknown, and may always be multiple, including environmental factors. Monogenetic determinants of ALS are involved in roughly 20% of all cases (including 10% familial cases). Less well understood multigenetic causes may contribute to another 20% to 80%. Environmental factors likely play a role in the development of ALS in susceptible...
متن کاملAre There Modifiable Environmental Factors Related to Amyotrophic Lateral Sclerosis?
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder of unknown etiology and no preventive treatment. It is characterized by degeneration of both upper motoneurons in the primary motor cortex and lower motoneurons in the brainstem and spinal cord. It results in progressive muscular weakness and atrophy, leading eventually to respiratory insufficiency and death. ...
متن کاملNeurotrophic Factors and Amyotrophic Lateral Sclerosis
The cause of motor neuron death in amyotrophic lateral sclerosis (ALS) remains a mystery. Initial implications of neurotrophic factor impairment involved in disease progression causing selective motor neuron death were brought forward in the late 1980s. These implications were based on several in vitro studies of motor neuron cultures in which a near to complete rescue of axotomized neonatal mo...
متن کاملNeurotrophic factors and amyotrophic lateral sclerosis.
The cause of motor neuron death in amyotrophic lateral sclerosis (ALS) remains a mystery. Initial implications of neurotrophic factor impairment involved in disease progression causing selective motor neuron death were brought forward in the late 1980s. These implications were based on several in vitro studies of motor neuron cultures in which a near to complete rescue of axotomized neonatal mo...
متن کاملGenetic Risk Factors for Amyotrophic Lateral Sclerosis
We performed a genome-wide association study in sporadic ALS (2,323 patients and 9,013 controls) and evaluated all SNPs with P < 1.0 x 10-4 in a second, independent cohort of 2,532 patients and 5,940 controls. Analysis of the genome-wide data revealed genome-wide signifi cance for one SNP, rs12608932 with P = 1.30 x 10-9. This SNP demonstrated robust replication in the second cohort (P = 1.86 x...
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ژورنال
عنوان ژورنال: Functional Neurology
سال: 2016
ISSN: 0393-5264
DOI: 10.11138/fneur/2016.31.1.007