Amyloid β production along the neuronal secretory pathway: Dangerous liaisons in the Golgi?

Dangerous liaisons

Cells during mitosis and meiosis undergo chromosome condensation through a process that depends on evolutionary conserved large protein complexes known as condensins. There are two condensing complexes, condensin i and ii, each of which is composed of five subunits. Condensin i and ii play essential, yet distinct, roles in chromosome condensation and segregation during mitosis. Recent findings ...

Dangerous liaisons at the virological synapse.

Cell-to-cell viral transmission facilitates the propagation of HIV-1 and human T cell leukemia virus type 1. Mechanisms of cell-to-cell transmission by retroviruses were not well understood until the recent description of virological synapses (VSs). VSs function as specialized sites of immune cell-to-cell contact that direct virus infection. Deciphering the molecular mechanisms of VS formation ...

Smoking and asthma: dangerous liaisons.

Cigarette smoking and asthma interact to induce important adverse effects on clinical, prognostic and therapeutic outcomes. This review examines recent evidence on the harmful effects of smoking in asthma, possible underlying inflammatory mechanisms for this altered response, management options for these patients and potential future therapeutic directions. Active smokers, particularly females,...

Ferritin and metallothionein: dangerous liaisons.

Ferritin (Ft) interaction with the Zn-complexes of mammalian MT1, MT2 and MT3 metallothioneins (MT) leads to simultaneous Fe(II) and Zn(II) release.

Dangerous liaisons? Industry relations with health professionals.