Amyloid precursor protein secretion and βA4 amyloid generation are not mutually exclusive
نویسندگان
چکیده
منابع مشابه
Late compartments of amyloid precursor protein transport in SY5Y cells are involved in beta-amyloid secretion.
Amyloid plaques, composed mainly of the 39-43 amino acid betaA4 peptide, are a characteristic feature of Alzheimer's disease. Generation of betaA4 by proteolytic processing of the amyloid precursor protein (APP) is thought to occur in a pathway that includes the activity of two as yet unknown proteases, with beta-secretase cleaving at the N terminus and gamma-secretase releasing the C terminus ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1994
ISSN: 0014-5793
DOI: 10.1016/0014-5793(94)00671-7