Amyloid precursor protein isoforms differentially modulate amyloid‐beta metabolism
نویسندگان
چکیده
منابع مشابه
Statins differentially affect amyloid precursor protein metabolism in presymptomatic PS1 and non-PS1 subjects.
T he putative potential of statins to retard the onset and progression of Alzheimer disease (AD) remains controversial. Statin therapy may have the potential to increase nonamyloidogenic soluble amyloid precursor protein (sAPP ), thereby reducing -amyloid 42 (A 42) and the downstream markers of neurodegeneration phospho-tau (p-tau) and total tau in the cerebrospinal fluid, and thus potentially ...
متن کاملCathepsins B and L differentially regulate amyloid precursor protein processing.
Previous studies have shown that cathepsins control amyloid beta (Abeta) levels in chromaffin cells via a regulated secretory pathway. In the present study, this concept was extended to investigations in primary hippocampal neurons to test whether Abeta release was coregulated by cathepsins and electrical activity, proposed components of a regulated secretory pathway. Inhibition of cathepsin B ...
متن کاملCellular and molecular basis of beta-amyloid precursor protein metabolism.
In molecular neurobiology, perhaps no molecule has been as thoroughly examined as Alzheimer's beta-amyloid precursor protein (betaAPP). In the ten years since the cDNA encoding betaAPP was cloned, the protein has been the subject of unparalleled scrutiny on all levels. From molecular genetics and cellular biology to neuroanatomy and epidemiology, no scientific discipline has been left unexplore...
متن کاملCellular and molecular basis of ß-amyloid precursor protein metabolism
1. Abstract 2. Introduction 3. Discussion 3.1. ßAPP Structure Gives Clues to its Function 3.1.1. ßAPP is Trafficked and Processed Through the Secretory Pathway 3.1.2. α-Secretase cleaves βAPP at the Cell Surface 3.1.3. Alternative ßAPP Metabolism Gives Rise to the Amyloid-ß Peptide 3.2. Intracellular Generation of Aß 3.2.1. Presenilin Mutations Support the Aß Hypothesis 3.3. Cellular Biology of...
متن کاملamyloid precursor protein processing in alzheimer’s disease
how to cite this article: bhadbhade a, cheng dw. amyloid precursor protein processing in alzheimer’s disease. iranian journal of child neurology2012;6(1):1-5. alzheimer’s disease (ad) is a progressive neurodegenerative disorder and a leading cause of dementia. the ad is characterized by presence of intraneuronal tangles and extracellular plaques in the brain. the plaques are composed of dense a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.823.13