Amyloid Plaque Imaging with a Targeted MRI Contrast Agent in a Transgenic Mouse Model of Alzheimer’s Disease
نویسندگان
چکیده
منابع مشابه
A peptide-targeted MRI contrast agent for cancer molecular imaging
Introduction: Early detection and diagnosis of malignant tumors enable more efficacious cancer treatment at an earlier stage and improvement of cancer patients' survival and quality of the life. Magnetic resonance imaging (MRI) is a powerful imaging modality for cancer detection and diagnosis. However, current clinically used contrast enhanced MRI is not effective for molecular imaging because ...
متن کاملA multimodal, β-amyloid-targeted contrast agent.
A multimodal, β-amyloid-targeted contrast agent was synthesized and studied in vitro. The agent has a higher relaxivity than a clinically approved contrast agent and interacts with β-amyloid aggregates producing changes in relaxation rate and fluorescence emission.
متن کاملEnvironmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease.
Epidemiological studies of Alzheimer patients from a wide variety of ethnic and socioeconomic backgrounds have identified education and occupation as environmental factors that can affect the risk of developing disease. A model of environmental manipulation in rodents uses enriched housing to provide cognitive and social stimulation. Previous studies have established elevations in synaptic numb...
متن کاملGlucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI
Background: Glucose transporter (Glut), a cellular transmembrane receptor, has a key role in the metabolism of cell glucose and is also associated with various human carcinomas.Objective: In this study, we evaluated a magnetic resonance (MR) imaging contrast agent for tumor detection based on paramagnetic gadolinium oxide (Gd2O3) coated polycyclodextrin (PCD) and mod...
متن کاملA novel MRI contrast agent synthesized by ion exchange method
Objective: In this study, the zeolite-coated iron oxide nanoparticles were evaluated as MRI contrast agent and effect of the nanocomposite synthesis method on MRI contrast was tested. Materials and Methods: Ion exchange method was used for synthesis of iron oxide-zeolite and the as prepared nanocomposite was characterized by XRD, FESEM and TEM. The nanocomposite toxicity in the cell culture, a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2022
ISSN: ['1176-9114', '1178-2013']
DOI: https://doi.org/10.2147/ijn.s351830