Amyloid-Mediated Mechanisms of Membrane Disruption

Protein aggregation and amyloid formation are pathogenic events underlying the development of an increasingly large number human diseases named “proteinopathies”. Abnormal accumulation in affected tissues ? (A?) peptide, islet polypeptide (IAPP), prion protein, to mention a few, involved occurrence Alzheimer’s (AD), type 2 diabetes mellitus (T2DM) diseases, respectively. Many reports suggest that toxic properties aggregates correlated with their ability damage cell membranes. However, molecular mechanisms causing amyloid/membrane interactions still far be completely elucidated. This review aims at describing mutual relationships linking abnormal protein conformational transition self-assembly into membrane damage. A cross-correlated analysis all these closely intertwined factors is thought provide valuable insights for comprehensive description and, turn, design effective therapies.