Amyloid beta mediates memory formation

Brief Communication Amyloid beta mediates memory formation

The amyloid precursor protein (APP) undergoes sequential cleavages to generate various polypeptides, including the amyloid b (1–42) peptide (Ab[1–42]), which is believed to play a major role in amyloid plaque formation in Alzheimer’s disease (AD). Here we provide evidence that, in contrast with its pathological role when accumulated, endogenous Ab in normal hippocampi mediates learning and memo...

satureja bachtiarica methanolic extract ameliorate beta amyloid induced memory impairment

Thermodynamic Description of Beta Amyloid Formation

Protein function depends on both protein structure and amino acid (aa) sequence. Here we show that modular features of both structure and function can be quantified from the aa sequences alone for the small (40,42 aa) plaque-forming amyloid beta fragments. Some edge and center features of the fragments are predicted. Contrasting results from the second order hydropathicity scale based on evolut...

Thermodynamics of beta-amyloid fibril formation.

Amyloid fibers are aggregates of proteins. They are built out of a peptide called beta-amyloid (Abeta) containing between 41 and 43 residues, produced by the action of an enzyme which cleaves a much larger protein known as the amyloid precursor protein (APP). X-ray diffraction experiments have shown that these fibrils are rich in beta-structures, whereas the shape of the peptide displays an alp...

Caspase-2 mediates neuronal cell death induced by beta-amyloid.

beta-amyloid (Abeta) has been proposed to play a role in the pathogenesis of Alzheimer's disease (AD). Deposits of insoluble Abeta are found in the brains of patients with AD and are one of the pathological hallmarks of the disease. It has been proposed that Abeta induces death by oxidative stress, possibly through the generation of peroxynitrite from superoxide and nitric oxide. In our current...