منابع مشابه
P135: The Role of Amyloid Beta-Peptides and Tau Protein in Alzheimer\'s Disease
Alzheimer's desease is the most common age-related neurodegenerative disorder, and cognitive problems such as defects in learning and memory are of its symptoms. Among the factors involved in the pathogenesis of the disease are biochemical disorders in protein production, oxidative stress, decreased acetylcholine secretion and inflammation of the brain tissue. Extra-neuronal accumulation ...
متن کاملAmyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance
Accumulation of the amyloid-beta (Aβ) peptide is a central factor in Alzheimer's disease (AD) pathogenesis as supported by continuing evidence. This review concisely summarizes this evidence supporting a critical role for Aβ in AD before discussing the clearance of this peptide. Mechanisms of clearance of Aβ are critical for preventing pathological elevations in Aβ concentration. Direct degrada...
متن کاملAmyloid Beta, Neural Lipids, Cholesterol & Alzheimer's Disease
To date great number of articles were devoted to cholesterol (chol) but only few articles studied the role for chol in neuron function/degeneration. For decades this molecule had been known to be important for atherosclerosis and heart disease. First indication of the involvement of chol in Alzheimer disease (AD), however, come from the mid 1990s. At that time it was shown that heart disease pa...
متن کاملThe effect of interval training with curcumin supplementation on LRP1 and beta amyloid levels in rats with Alzheimer's disease
Background and aims: Beta amyloid protein (Aβ) deposition in the brain is a hallmark of Alzheimer's disease (AD). The aim of the present study was to investigate the effect of a moderate-intensity interval training with curcumin supplementation on plasma levels of LRP1 (as the main carrier of Aβ in plasma) and Aβ levels in plasma and brain of induced AD rats. Methods: Fifty Wistar rats (eigh...
متن کاملEffect of creatine supplementation on cognitive performance and apoptosis in a rat model of amyloid-beta-induced Alzheimer's disease
Objective(s): Neuroprotective effect of creatine (Cr) against β-amyloid (Aβ) is reported in an in vitro study. This study investigated the effect of Cr supplementation on β-amyloid toxicity in vivo. Materials and Methods: Thirty two, male Wistar rats were divided into 4 groups. During ten weeks of study, control group went through no surgical or dietary intervention. At the 4th week of study S...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2015
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2015.01.013