Amygdala Regulation of Nucleus Accumbens Dopamine Output is Governed by the Prefrontal Cortex

Amygdala regulation of nucleus accumbens dopamine output is governed by the prefrontal cortex.

A dynamic interaction between the prefrontal cortex (PFC), amygdala, and nucleus accumbens (NAc) may be fundamental to regulation of goal-directed behavior by affective and cognitive processes. This study demonstrates that a mechanism for this triadic relationship is an inhibitory control by prefrontal cortex on accumbal dopamine release during amygdala activation. In freely moving rats, micros...

The contribution of the amygdala, nucleus accumbens, and prefrontal cortex to emotion and motivated behaviour

Emotion and motivation depend on the assessment of the value of environmental stimuli. Multiple representations of stimulus value are created in the brain by Pavlovian and instrumental conditioning procedures. The basolateral amygdala (BLA) appears necessary for a Pavlovian conditioned stimulus (CS) to gain access to the current value of the specific unconditioned stimulus (US) that it predicts...

The amygdala regulates information flow from the prefrontal cortex to the nucleus accumbens

Involvement of Dopamine in the Nucleus Accumbens and Prefrontal Cortex in Cocaine-associative Learning

Effects of antipsychotic drugs on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens.

The present study was designed to compare the effects of typical and atypical antipsychotic drugs on extracellular dopamine (DA) levels in the medial prefrontal cortex (mPFC) and the nucleus accumbens (NAC), using in vivo microdialysis with dual probe implantation in awake, freely moving rats. Amperozide (2 and 10 mg/kg), clozapine (5 and 20 mg/kg), and olanzapine (10 mg/kg), all of which are a...