AmruthMune, A Standardized Extract Comprises of Tinosporin from Tinospora cordifolia and its Mechanism of Immunostimulatory Activity

Abstract: Background: Tinospora cordifolia is an illustrious medicinal herb in Indian traditional ayurvedic medicine because of its substantial properties. It reported that has been used to cure for many ailments by practitioners. captivating that, this contemporary world being retain good immune health. Materials and Methods: The objective research demonstrate the enhancing activity AmruthMune a standardized extract T. with Tinosporin. MTT assay, NO H2O2 Phagocytosis ELISA, western blotting experiments were conducted study understand efficacy basic molecular mechanism. Results: Quantitative HPLC analysis determined comprise active principle Tinosporin (1%). In addition, treatment dramatically improved phagocytosis secretion NO, TNF-α, IL-6 macrophage cells. Furthermore, consequences blot demonstrated activates p-ERK, p-p38 p-JNK. Conclusion: Collectively, these results exhibited MAPK signalling pathway involved elicited activation it could be promising functional food modulation. Keywords:Immune modulation, Murine macrophages, Phagocytosis, pathway.