Ampicillin Treatment of Typhoid Carriers

Ampicillin Treatment of Typhoid Carriers.

THE change in the clinical course of typhoid fever due to treatment with chloramphenicol has been one of the more dramatic triumphs of the antibiotic age. A prolonged fever has been converted into a short sharp febrile illness, so that the patient suffering from the disease, instead of being dangerously ill for several weeks, may well be sitting up in bed after three or four days on chloramphen...

Treatment of chronic typhoid carriers with ampicillin.

Ten chronic enteric typhoid carriers treated with oral ampicillin have been followed for 4 to 9 years and no relapses have occurred. Patients are probably cured if relapse does not occur within 2 years.

Typhoid Fever and Typhoid Carriers

Chloramphenicol combined with ampicillin in treatment of typhoid.

Fifty out of 100 patients with typhoid fever, matched for age, stage of illness, and degree of fever, were treated with chloramphenicol and the other 50 were treated with chloramphenicol combined with ampicillin. The febrile period was shortened by up to 29% in patients treated with the combined drugs compared with those given only chloramphenicol. Moreover, no patient on combined therapy had a...

[Prevalence of typhoid carriers after treatment with chloramphenicol].

William Budd (1)) anticipating the discovery of the typhoid bacillus by 24 years, probably intuited the existence of carriers when he said that “the first case may be foreign or may be due to the local poison that arises, like a fire from its ashes, as a sleeping legacy from a similar previous outbreak.” At the end of the nineteenth century, Koch demonstrated clearly the role of the human being...